Expert Opin Pharmacother. Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties.
Embryonic stem cell transplantation: potential applicability in cell replacement therapy and regenerative medicine.
The concentration of serum TSG-6 was calculated based on a standard curve.Total RNA was extracted from colon samples or cells using TRIzol Reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer’s instructions.
This review aims to introduce the biology of skin and wound healing, the application of adipose-derived stem cells in wound healing, and regeneration in terms of their differentiation potential, paracrine potential, combined biomaterials, hypoxic conditions, and clinical trials (Table (Table1 1). Topical delivery of mesenchymal stem cells and their function in wounds. Unfortunately, angiogenesis is diminished in the hypoxic environment of chronic wounds. Stem Cells Int. Chemotactic signals including platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) are released and attract macrophages, neutrophils, and fibroblasts to the wound bed. 2015;36(13):806–16.Patsch C, Challet-Meylan L, Thoma EC, Urich E, Heckel T, O'Sullivan JF, et al. Prockop, D. J., Kota, D. J., Bazhanov, N. & Reger, R. L. Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs).
Mesenchymal stem cells promote diabetic corneal epithelial wound healing through TSG-6-dependent stem cell activation and macrophage switch. These can cause bowel obstructions, chronic pain, and infertility.Application of stem cells have been explored in many other injury settings, such as a kidney diseases including acute kidney injury, chronic kidney disease such as diabetic renal disease, and glomerulosclerosis, and in the setting of kidney transplant.Tissue repair and regeneration exists on a spectrum, from keloids, hypertrophic scarring, and fibrosis to functional tissue regeneration. Biology and potential therapeutic valueCardiac myocyte cell cycle control in development, disease, and regenerationCardiac stem cells and mechanisms of myocardial regenerationBiologic properties of endothelial progenitor cells and their potential for cell therapyEndothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regenerationCochrane corner: stem cell therapy for chronic ischaemic heart disease and congestive heart failureComparison of allogeneic vs autologous bone marrow‐derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trialTranscoronary transplantation of progenitor cells after myocardial infarctionA randomized, double‐blind, placebo‐controlled, dose‐escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarctionTransendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC‐HFT randomized trialStem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow‐derived mesenchymal stromal cellsMesenchymal stem cells and chronic renal artery stenosisHuman hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogrammingDirect reprogramming of human fibroblasts to functional and expandable hepatocytesHuman pluripotent stem cells: myths and future realities for liver cell therapyFeasibility and safety of G‐CSF administration to induce bone marrow‐derived cells mobilization in patients with end stage liver diseaseAutologous bone marrow stem cell transplantation in patients with liver failure: a meta‐analytic reviewHuman umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patientsImproved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapyStem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cellsHuman fetal liver‐derived stem cell transplantation as supportive modality in the management of end‐stage decompensated liver cirrhosisDirect reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosisIn vivo hepatic reprogramming of myofibroblasts with AAV vectors as a therapeutic strategy for liver fibrosisEngineering functional two‐ and three‐dimensional liver systems in vivo using hepatic tissue sheetsIn vivo construction of liver tissue by implantation of a hepatic non‐parenchymal/adipose‐derived stem cell sheetAdipose‐tissue‐derived stem cells enhance the healing of ischemic colonic anastomoses: an experimental study in ratsAutologous expanded adipose‐derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: Fistula Advanced Therapy Trial 1) and long‐term evaluationExpanded allogeneic adipose‐derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double‐blind controlled trialIntra‐abdominal adhesions: anatomy, physiology, pathophysiology, and treatmentStem cells for mesothelial repair: an understudied modalityMesenchymal stem cell‐based therapy for kidney disease: a review of clinical evidenceThe effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies, Small molecule inhibitor of HSP47 prevents pro-fibrotic mechanisms of fibroblasts in vitro, Biochemical and Biophysical Research Communications, Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses, Cell Sheets from Adipose Tissue MSC Induce Healing of Pressure Ulcer and Prevent Fibrosis via Trigger Effects on Granulation Tissue Growth and Vascularization, Understanding the mechanism of radiation induced fibrosis and therapy options,
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